GenoITS is a computational package that performs the regulatory workflow proposed by REACH for the genotoxicity prediction of chemicals.
QSAR models in GenoITS
In vitro gene mutation study in bacteria (Ames test)
REACH code: 8.4.1
In vitro cytogenicity study in mammalian cells (chromosomal aberration)
REACH code: 8.4.2
In vitro gene mutation study in mammalian cells (Hprt assay)
REACH code: 8.4.3
In vivo cytogenicity study in somatic cells (micronucleus assay)
REACH code: 8.4.4
In vivo gene mutation study in somatic cells (comet assay)
GenoITS is a computational workflow focused on the prediction of genotoxicity using the Integrated Testing Strategy proposed by REACH.
GenoITS uses 5 different QSAR models to perform the complete workflow, one per each kind of study demanded by REACH (Gene Mutation in bacteria; in vitro cytogenicity; in vitro gene mutation; in vivo cytogenicity; in vivo gene mutation). GenoITS also allows the users to supply their own experimental data.
REACH also promotes alternative methods for the hazard assessment of substances in order to reduce the number of tests on animals. The requirements for registering a chemical substance are organized as annexes of the REACH regulation. Different annexes must be used depending on the substance mass produced or imported.
GenoITS was developed as a part of the GenoQSAR research project (https://protoqsar.com/genoqsar/). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101030422.
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