ProtoPHYSCHEM is a module focused on the prediction of endpoints related with the physicochemical properties of chemical substances.

ProtoPHYSCHEM mainly includes, but is not limited to, endpoints used by REACH, a European Union regulation, adopted to improve the protection of human health and the environment from the risks that can be posed by chemicals, while enhancing the competitiveness of the EU chemicals industry.

REACH also promotes alternative methods for the hazard assessment of substances in order to reduce the number of tests on animals. The requirements for registering a chemical substance are organized as annexes of the REACH regulation. Different annexes must be used depending on the substance mass produced or imported by each company.