ProtoICH is a computational application for the prediction of
mutagenicity of chemical compounds, by using proprietary (Q)SAR models.
Models in ProtoICH
Statistical method (QSAR)
Expert-rule based method
ProtoICH is specially focused on ICH M7 Guideline,
aimed to reduce the potential carcinogenic risk of impurities. ICH M7 Guideline
proposes the use of computational methods as an alternative for mutagenicity assays.
It requires the prediction by means of two computational metodologies: a statistical
method (QSAR) and an expert-rule based method.