ProtoICH is a computational application for the prediction of mutagenicity of chemical compounds, by using proprietary (Q)SAR models.



Models in ProtoICH

Statistical method (QSAR)

Expert-rule based method



ProtoICH is specially focused on ICH M7 Guideline, aimed to reduce the potential carcinogenic risk of impurities. ICH M7 Guideline proposes the use of computational methods as an alternative for mutagenicity assays. It requires the prediction by means of two computational metodologies: a statistical method (QSAR) and an expert-rule based method.