ProtoADME

ProtoADME is a computational tool for the prediction of ADME properties of chemical compounds, by using proprietary QSAR models.

ABSORPTION

Bioavailability 20%

Bioavailability 30%

Caco-2 permeability

Human Intestinal Absorption

P-glycoprotein inhibitor

P-glycoprotein substrate

Skin permeability

DISTRIBUTION

Blood-brain barrier penetration

Plasma protein binding

Volume of distribution

METABOLISM

CYP450 1A2 inhibitor

CYP450 3A4 inhibitor

CYP450 2C9 inhibitor

CYP450 2C19 inhibitor

CYP450 2D6 inhibitor

CYP450 1A2 substrate

CYP450 3A4 substrate

CYP450 2C19 substrate

CYP450 2D6 substrate

EXCRETION

Half life

Human liver microsome (HLM) stability

OATP1B1 inhibitor

OATP1B3 inhibitor

BSEP inhibitor

ProtoADME is focused on ADME (Absorption, Distribution, Metabolism and Excretion) properties.