ProtoADME is a computational application for the prediction of ADME properties of chemical compounds, by using proprietary QSAR models.



ABSORPTION

Bioavailability 20%

Bioavailability 30%

Caco-2 permeability

Human Intestinal Absorption

P-glycoprotein inhibitor

P-glycoprotein substrate

Skin permeability

DISTRIBUTION

Blood-brain barrier penetration

Fraction unbound

Plasma protein binding

Volume of distribution

METABOLISM

CYP450 1A2 inhibitor

CYP450 2C19 inhibitor

CYP450 2C9 inhibitor

CYP450 2D6 inhibitor

CYP450 3A4 inhibitor

CYP450 1A2 substrate

CYP450 2C19 substrate

CYP450 2C9 substrate

CYP450 2D6 substrate

CYP450 3A4 substrate

Human liver microsome (HLM) stability

EXCRETION

Clearance

Half life



ProtoADME is focused on ADME (Absorption, Distribution, Metabolism and Excretion) properties.