ProtoTOX is a computational application for the prediction of toxicological properties of chemical compounds, by using proprietary QSAR models.



QSAR models in ProtoTOX

Skin irritation

REACH code: 8.1.1

Eye irritation

REACH code: 8.2.2

Skin sensitisation

REACH code: 8.3

Mutagenicity (Ames test)

REACH code: 8.4.1

Genotoxicity (micronucleus)

REACH code: 8.4.2

Chromosomal aberration

REACH code: 8.4.3

Acute oral

REACH code: 8.5.1

Developmental toxicity

REACH code: 8.7.2

Carcinogenicity

REACH code: 8.9.1

Neurotoxicity



ProtoTOX is a module focused on the prediction of endpoints related with the toxicity of chemical substances. It includes a variety of in vitro and in vivo tests in humans, animals, microorganisms and cell lines.

ProtoTOX mainly includes, but is not limited to, endpoints used by REACH, a European Union regulation, adopted to improve the protection of human health and the environment from the risks that can be posed by chemicals, while enhancing the competitiveness of the EU chemicals industry.

REACH also promotes alternative methods for the hazard assessment of substances in order to reduce the number of tests on animals. The requirements for registering a chemical substance are organized as annexes of the REACH regulation. Different annexes must be used depending on the substance mass produced or imported by each company.