ProtoECO is a module focused on the prediction of endpoints related with ecotoxicity and the environmental effects of chemical substances. This includes properties related to the distribution and degradation of substances in the environment as well as their toxic effects in the biota.

ProtoECO mainly includes, but is not limited to, endpoints used by REACH, a European Union regulation, adopted to improve the protection of human health and the environment from the risks that can be posed by chemicals, while enhancing the competitiveness of the EU chemicals industry.

REACH also promotes alternative methods for the hazard assessment of substances in order to reduce the number of tests on animals. The requirements for registering a chemical substance are organized as annexes of the REACH regulation. Different annexes must be used depending on the substance mass produced or imported by each company.